Posts Tagged ‘Cannabigerol’

See an updated version of this post on The Leaf Online, Cannabinoid Profile – CBGa!

Formula: C22H32O4
Molecular Mass: 360.48708 g/mol
Decarboxylation Point: ????

Boiling Point: ????

LD50 (Lethal Dose): Currently Unknown, likely similar to CBG, 300mg/kg for mice  (Compare to Nicotine: for mice – 3mg/kg for humans – 40–60 mg/kg),

Cannabigerolic acid (CBGa) is formed when geranyl pyrophosphate combines with olivetolic acid within the cannabis plant. It is thanks to CBGa that all other medicinal effects of cannabis are possible. Cannabigerolic acid (CBGa) can be thought of as the stem cell cannabinoid, which becomes THCa/THC, CBDa/CBD, CBCa/CBC, and CBG. It does this through different types of biosynthesis, where chemicals combine to form new compounds, examples being the  THC biosynthase and the CBD biosynthase. During these different chemical processes the acid grou Hemp species of cannabis have higher amounts of CBG due to a recessive trait, which may imply higher amounts of CBGa present in those strains as well.

Image Courtesy of Steephill/Halent Labs and Elemental Wellness

Image Courtesy of Steephill/Halent Labs and Elemental Wellness

Therapeutic Uses

Analgesic – Relieves pain.

Antibacterial – Slows bacterial growth.

Anti-inflammatory – Reduces inflammation systemically.

Anti-Proliferative – Inhibits cancer cell growth through apoptosis.

 

Halent 2011 - Cannabinoid and Terpenoid Chart

 

 

Currently Being Studied For

Cannabinoid Biosynthase: Nearly all current research on CBGa focuses solely on its role in the biosynthesis of other cannabinoids. Virtually no money is going to study its analgesic, antibacterial, anti-inflammatory, and anti-proliferative properties.

We learned in 2005 that the enzyme controlling the conversion of CBGa into THCa and further THC is held within the trichomes of the plant. This makes sense, as the trichomes have long been known to be the home of THC. Sirikantaramas did a follow up study on his 2005 research which showed they could grow THCa in a laboratory using a yeast culture as a host. If you want to know more about the THCa synthase, which is the first biosynthase to see any major study, you can look at this 2009 literature review profiling it. It wasn’t until 2014 that any of this research turned back to focus on CBGa again, when Alaoui et Al (2014) identified how and where CBGa binding happened, then explored how it was converted into THCa. Their research could be key to better understanding how THCa production happens and thus how much THCa will be resulting in the plant material.

Cancer: While there are no current studies being done on CBGa for it’s abilities to help with cancer it has been shown to be an anti-proliferative just like CBG, THC, and CBD. CBGa encourages apoptosis, which is programmed cell death. Defective apoptosis is believed to be a major reason for the formation and progression of cancer, one obvious solution to a person having depressed levels of apoptosis is to stimulate that bodily response. Cannabinoids appear to stimulate apoptosis in previously unknown ways posing a novel way to mitigate and potentially cure cancer. While this much is known about CBGa more research should be done.

*Note: Decarboyxlation – A chemical reaction that removes a carboxyl group and releases  CO2, often triggered by heat.

See an updated version of this post on The Leaf Online,Cannabinoid Profile – CBG!

Cannabigerol
Formula: C21H32O2
Molecular Mass: 314.2246 g/mol
Decaboxylation Point: ????
Boiling Point:  ????
LD50 (Lethal Dose): 300mg/kg for mice (Compare to Nicotine: for mice – 3mg/kg for humans – 40–60 mg/kg)

Cannabigerol (CBG) is not considered psychoactive  and is known to block the psychoactive effects of THC.  It has been shown to stimulate the growth of new brain cells and bones. Neurogenic compounds are extremely rare which makes CBG a very worthwhile subject for more research. CBG also is antibacterial, anti-tumor, and aids with insomnia. It is effectively impossible to overdose on CBG; it usually exists only in trace amounts in a processed plant, this makes the already very high LD50 of 22.44g/kg even less. CBG is considered a ‘stem cell’ cannabinoid and can change into different cannabinoids, altering the overall effects of the plant. Some of these cannabinoids CBG morphs into are  THC ,CBD, and CBC which all share the same molecular formula but have a different structure.

Therapeutic Uses

Analgesic – Relieves pain.

Antibacterial – Slows bacterial growth.
Anti-Inflammatory – Reduces inflammation systemically.
Anti-Insomnia – Aids with sleep.
Anti-Proliferative – Inhibits cancer cell growth.
Bone Stimulant – Promotes bone growth.
Neurogenic – Helps stimulate the growth of new brain cells.

Currently Being Studied For

Glaucoma: A 2009 study found both CBG and THC to be very effective for relieving the intraocular pressure from glaucoma. This is an area that will undoubtedly be receiving more research in the years to come.

Inflammatory Bowel Disease: Much like CBD, CBG shows a lot of potential for controlling the inflammation that leads to IBD, and like CBD warrants further research.

Painkiller and Anti- Inflammatory: Recent research suggests that CBG has anti-inflammatory and analgesic properties and recommends further study.

5-HT1a Receptor Agonist/Antagonist?: CBG appears to do something at the 5-HT1a receptor that is not fully understood. It modulates how other cannabinoids affect us especially at this brain site, which is the hub of emotions and depression regulation in the brain. Depending on the study evidence suggests that CBG may help your depression and anxiety, or possibly block certain anti-depressant drugs. One study in rodents showed that if the right combination of CBG and CBD were present the CBG would block some of the anti-nausea effects of the CBD, but it could not quite identify why (other than it related to the 5HT1a receptor).

Dravet Syndrome/Seizures: Anecdotal evidence and some current studies suggest that CBG may be beneficial to patients with Dravet and other seizure conditions. A new tincture was just released at Harborside Health Center which is the first CBG-rich tincture on the market. This tincture, named Jayden’s Juice after Jayden David, the young boy with Dravet syndrome made famous by Weed Wars, is currently what Jayden is using to combat his seizures instead of a purely CBD rich tincture. A study from earlier this year also suggests that CBG may help with seizure management, but the mechanisms aren’t fully understood.

Halent 2011 - Cannabinoid and Terpenoid Chart

References:

  1. Steep Hill Lab, Cannabinoid and Terpenoid Reference Guide; http://steephilllab.com/resources/cannabinoid-and-terpenoid-reference-guide/
  2. Skunk Pharm Research, Cannabinoid and Terpene Info; http://skunkpharmresearch.com/cannabinoid-info/
  3. SC Labs, Meet the Cannabinoids; http://sclabs.com/learn/learn-cannabinoids.html

*Note: Decarboyxlation – A chemical reaction that removes a carboxyl group and releases  CO2, often triggered by heat.